标题（中文）：

标题（英文）：Palladium-Catalyzed Selective Synthesis of Dibenzo[c,e]azepin-5-ols and Benzo[c]pyrido[2,3-e]azepin-5-ols

刊物名称：Advanced Synthesis and Catalysis（DOI: 10.1002/adsc.201900705）

作者姓名（中文）：姚鑫容 邵银林 胡茂林 张茂生 李绍彤 夏远志 程天行 陈久喜

作者姓名（英文）：Xinrong Yao, Yinlin Shao, Maolin Hu, Maosheng Zhang, Shaotong Li, Yuanzhi Xia, Tianxing Cheng, and Jiuxi Chen*

摘要（英文）：An efficient palladium-catalyzed tandem addition/cyclization of 2’-formyl-[1,1’-biaryl]-2-carbonitriles with arylboronic acids is reported. This reaction affords dibenzo[c,e]azepin-5-ols and benzo[c]pyrido[2,3-e]azepin-5-ols with excellent selectivity and wide functional group compatibility. The dibenzo[c,e]azepin-5-ols show good cell growth inhibitory activity against a triple-negative breast cancer cell line. Moreover, the proposed mechanistic rationale for this tandem process is supported by theoretical calculations.

原文链接：https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201900705