标题(中文):硒自由基介导的串联环化:硒化苯并呋喃(苯并噻吩)的合成
标题(英文):Selenium Radical Mediated Cascade Cyclization: Concise Synthesis of Selenated Benzofurans (Benzothiophenes)
刊物名称及期号、页码: Organic Letters, 2019, 21, 6710-6714
作者姓名(中文):安翠,郦晨园,黄小波,高文霞,周云兵,刘妙昌,吴华悦
作者姓名(英文):Cui An, Chen-Yuan Li, Xiao-Bo Huang, Wen-Xia Gao, Yun-Bing Zhou*, Miao-Chang Liu*, Hua-Yue Wu.
摘要(英文):Presented in this work is a novel methodology for the synthesis of selenated benzofurans (or benzothiophenes) via AgNO2-catalyzed radical cyclization of 2-alkynylanisoles (or 2-alkynylthioanisoles), Se powder, and arylboronic acids. This method enables the construction of a benzofuran (benzothiophene) ring, two C–Se bonds, and a C–O(S) bond as well as the cleavage of a C–O(S) bond in a single step. Preliminary mechanistic studies imply that the AgNO2-catalyzed cyclization proceeds via an aryl selenium radical intermediate.
原文链接: https://doi.org/10.1021/acs.orglett.9b02315