Nickel-Catalyzed Oxidative Cyclotrimerization of α-Amino Ketones: Selective Synthesis of Pyrazoles

    A new strategy for the synthesis of 3-methylene-2,3-dihydro-1H-pyrazoles is presented by Ni-catalyzed oxidative cyclotrimerization of α-amino ketones. This unprecedented method allows three α-amino ketones to undergo sequential multiple deprotonations and deamination through two C–C bonds and one N–N bond formation cascade.

原文：https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0033-1340014