Tetrabutylammonium Bromide Catalyzed Tandem Addition/Cyclization of  letter o-Aralkynylaryl Aldehydes with Trimethyl(trifluoromethyl)silane: Synthesis of Trifluoromethyl Group Containing Phthalans

 A tetrabutylammonium bromide catalyzed trifluoromethylation/cyclization reaction of o-aralkynylaryl aldehydes with trimethyl(trifluoromethyl)silane and cesium fluoride has been developed. A variety of 1-alkylidene-3-(trifluoromethyl)phthalans were prepared in moderate to excellent yields by tandem nucleophilic addition and cyclization.

原文：https://www.thieme-connect.com/ejournals/pdf/10.1055/s-0033-1340076.pdf?update=true